Infectivity and abnormal PrP in tissues from sheep exposed to Atypical Scrapie

Recently identified atypical/Nor98 cases represent an increasing problem. Incidence in EU countries seems to vary between 3 and 11 per 10 000 tested animals.

However because a probable lack of sensitivity in screening tests towards this particular TSE, this value is probably an underestimation.

There are no consistent information concerning the abnormal PrP or infectivity distribution in peripheral tissues of atypical cases. This absence of data, combined with the involvement of ARR/ARR animals that were believed to be resistant to TSE, represent a major concern with regards to the efficiency of the current food protection policy against TSE.

In this project considering that atypical cases could be either a spontaneous affection from central nervous system origin or an acquired infectious disease resulting from an oral contamination, we establish distribution of abnormal PrP (using the most appropriate tool available) and infectivity (using Tg mice model) in sheep tissues (like blood, muscle, CNS) and milk. These data should provide useful data for evaluation of potential food risk associated to atypical/ scrapie cases.

Samarbeidspartnere

  • Ecole Nationale Vétérinaire de Toulouse, INRA, France
  • LNIV Lisbon, Portugal

Forskninginformasjon

Start
2007-06-01
Slutt
2013-06-30
Prosjektnummer
DEFRA/FSA UK, prosjekt 2007021
Status
Ferdig
Finansiering
Andre Forskningsprosjekter
Forskningsområder
Patologi

Forskere

Sylvie Benestad

Senior forsker
Mobilnr: +47 97536830
E-post: sylvie.benestad@vetinst.no

Dyr